Bioinformatics explained: Reverse translation

In all living cells containing hereditary material such as DNA, a transcription to mRNA and subsequent a translation to proteins occur. This is of course simplified but is in general what is happening in order to have a steady production of proteins needed for the survival of the cell. In bioinformatics analysis of proteins it is sometimes useful to know the ancestral DNA sequence in order to find the genomic localization of the gene. Thus, the translation of proteins back to DNA/RNA is of particular interest, and is called reverse translation or back-translation.