- Windows 10, Windows 11, Windows Server 2016, Windows Server 2019 and Windows Server 2022
- Mac: macOS 11, 12, 13 and 14
- Linux: RHEL 7 and later, SUSE Linux Enterprise Server 12 and later. The software is expected to run without problem on other recent Linux systems, but we do not guarantee this. To use BLAST related functionality, libnsl.so.1 is required.
- 64 bit
- For CLC Server setups that include job nodes and grid nodes, those nodes must run the same type of operating system as the master CLC Server.
- File system that supports file locking
Server hardware requirements
- 16 GB RAM recommended (8 GB RAM required)
- Disk space: 500 GB required. More needed if large amounts of data are analyzed.
Performance note: Tools that take advantage of multiple cores do not scale linearly with high numbers of cores. If you plan to use a large system (>64 cores), a setup with job nodes running on virtual machines provides the potential to use more of the compute capacity. On a job node setup, analyses can be run in parallel, with appropriate cpu limits configurable for each node, as described in Configuring your job node setup.
For mapping reads to the human genome ( 3.2 gigabases), or genomes of a similar size, 16 GB RAM is required. Smaller systems can be used when mapping to small genomes.
Larger amounts of memory can help the overall speed of the analysis when working with large datasets, but little gain is expected above about 32 GB of RAM.
Increasing the number of cpus can decrease the time a read mapping takes, however performance gain is expected to be limited above approximately 40 threads.
De novo assembly may need more memory than stated above - this depends both on the number of reads and the complexity and size of the genome. See http://resources.qiagenbioinformatics.com/white-papers/White_paper_on_de_novo_assembly_4.pdf for examples of the memory usage of various data sets.
The file locking mechanism is required to ensure that all nodes see the latest version of the data stored on the shared filesystem.
Containerized external applications1.1 are supported for Unix images run on Unix hosts only. Windows-based images and Windows hosts are not supported. Standard external applications are supported for any CLC Server setup.