Enabling data compression may impose a performance penalty depending on the characteristics of the hardware used. However, this penalty is typically small, and we generally recommend that this option remains enabled. Turning this option off is likely to be of interest only at sites running a mix of older and newer CLC software, where the same data is accessed by different versions of the software.
- A new compression method was introduced with version 22.0 of the CLC Genomics Workbench, CLC Main Workbench and CLC Genomics Server. Compressed data created using those versions can be read by version 21.0.5 and above, but not earlier versions.
- Internal compression of CLC data was introduced in CLC Genomics Workbench 12.0, CLC Main Workbench 8.1 and CLC Genomics Server 11.0. Compressed data created using these versions is not compatible with older versions of the software. Data created using these versions can be opened by later versions of the software, including versions 22.0 and above.
To share specific data sets for use with software versions that do not support the compression applied by default, we recommend exporting the data to CLC or zip format and turning on the export option "Maximize compatibility with older CLC products". That is described further at https://resources.qiagenbioinformatics.com/manuals/clcgenomicsworkbench/current/index.php?manual=Export_folders_data_elements_in_CLC_format.html