Compare Immune Repertoires
The Compare Immune Repertoires tool contrasts properties of immune repertoires, such as diversity and similarity.
To run Compare Immune Repertoires go to the Toolbox and select:
Toolbox | Biomedical Genomics Analysis (
) | Immune Repertoire Analysis (
) | Compare Immune Repertoires (
)
This opens a dialog where a combination of TCR clonotypes (
) or BCR clonotypes (
), and Clonotype Sample Comparison (
) objects to be compared can be selected. Note that TCR and BCR clonotypes cannot be mixed and only one type should be used at a time.
In the next step, the following options are available:
- Resolve clonotypes with ambiguous segments. If checked, a clonotype in one sample with ambiguous V/D/J/C segments is resolved using a clonotype in another sample with unambiguous segments, where possible.
- Resolve clonotypes without C segment. If checked, a clonotype in one sample without a C segment is resolved using a clonotype in another sample with a C segment, where possible.
See Resolving of clonotypes for more details.
Subsections