CLC Genomics Workbench lets you convert an RNA sequence into DNA, substituting the U residues (Urasil) for T residues (Thymine):
select an RNA sequence in the Navigation Area | Toolbox in the Menu Bar | Classical Sequence Analysis () | Nucleotide Analysis ()| Convert RNA to DNA ()
or right-click a sequence in Navigation Area | Toolbox | Classical Sequence Analysis () | Nucleotide Analysis ()| Convert RNA to DNA ()
This opens the dialog displayed in figure 15.2:
If a sequence was selected before choosing the Toolbox action, this sequence is now listed in the Selected Elements window of the dialog. Use the arrows to add or remove sequences or sequence lists from the selected elements.
Click Next if you wish to adjust how to handle the results. If not, click Finish.
This will open a new view in the View Area displaying the new DNA sequence. The new sequence is not saved automatically. To save the sequence, drag it into the Navigation Area or press Ctrl + S ( + S on Mac) to activate a save dialog.
Note! You can select multiple RNA sequences and sequence lists at a time. If the sequence list contains DNA sequences as well, they will not be converted.