A good estimate for the memory required by the base space read mapper to represent a reference is one MB for each Mbp in the reference. For example the human reference genome requires of memory.
An additional 4GB of memory should be reserved for the CLC Genomics Workbench, and thus the recommended minimum amount of memory for mapping short high quality reads (e.g. Illumina reads) to the human genome is 8GB. However, when mapping long reads with a high error rate, such as PacBio reads, each CPU core can add several hundred MB to the total memory consumption. Consequently, mapping long reads with high error rate on a machine with many CPU cores, can cause a large increase in the memory requirements for all CLC read mappers.