Advanced preferences
Proxy Settings
CLC Main Workbench supports the use of an HTTP-proxy and an anonymous SOCKS-proxy.
You have the choice between an HTTP-proxy and a SOCKS-proxy. The CLC Workbench only supports the use of a SOCKS-proxy that does not require authorization.
You can select whether the proxy should also be used for FTP and HTTPS connections.
Figure 4.9: Advanced preference settings include proxy configuration options.
List hosts that should be contacted directly, i.e. not via the proxy server, in the Exclude hosts field. The value can be a list, with each host separated by a | symbol. The wildcard character * can also be used. For example: *.foo.com|localhost.
The proxy can be bypassed when connecting to a CLC Server, as described in CLC Server connection.
If you have any problems with these settings, contact your systems administrator.
Default data location
The default location is used when you import a file without selecting a folder or element in the Navigation Area first. It is set to the folder called CLC_Data in the Navigation Area, but can be changed to another data location using a drop down list of data locations already added (see Adding locations). Note that the default location cannot be removed, but only changed to another location.
Data Compression
CLC format data is stored in an internally compressed format. The application of internal compression can be disabled by unchecking the option "Save CLC data elements in a compressed format". This option is enabled by default. Turning this option off means that data created may be larger than it otherwise would be.
Enabling data compression may impose a performance penalty depending on the characteristics of the hardware used. However, this penalty is typically small, and we generally recommend that this option remains enabled. Turning this option off is likely to be of interest only at sites running a mix of older and newer CLC software, where the same data is accessed by different versions of the software.
Compatibility information:
- A new compression method was introduced with version 22.0 of the CLC Genomics Workbench, CLC Main Workbench and CLC Genomics Server. Compressed data created using those versions can be read by version 21.0.5 and above, but not earlier versions.
- Internal compression of CLC data was introduced in CLC Genomics Workbench 12.0, CLC Main Workbench 8.1 and CLC Genomics Server 11.0. Compressed data created using these versions is not compatible with older versions of the software. Data created using these versions can be opened by later versions of the software, including versions 22.0 and above.
To share specific data sets for use with software versions that do not support the compression applied by default, we recommend exporting the data to CLC or zip format and turning on the export option "Maximize compatibility with older CLC products". See Export of folders and data elements in CLC format.
NCBI Integration
Without an API key, access to NCBI from asingle IP-address is limited to 3 requests per second; if many workbenches use the same IP address when running the Search for Sequences at NCBI and Search for PDB Structures at NCBI tools they may hit this limit. In this case, you can create an API key for NCBI E-utilities in your NCBI account and enter it here.
NCBI BLAST
The standard URL for the BLAST server at NCBI is: https://blast.ncbi.nlm.nih.gov/Blast.cgi, but it is possible to specify an alternate server URL to use for BLAST searches. Be careful to specify a valid URL, otherwise BLAST will not work.