Overview of CLC LightSpeed Module
The CLC LightSpeed Module offers specialized tools for fast, accurate variant calling for germline, somatic, and tumor-normal analyses, taking FASTQ files as input.
It supports whole-genome sequencing (WGS), whole-exome sequencing (WES), and QIAseq targeted panels, with an end-to-end solution supporting the following optional steps:
- Quality Trimming
- Adapter Trimming
- Read Mapping
- Deduplication
- Local Realignment
- UMI Grouping
- Primer Trimming
- Variant Calling
- QC Reporting
A set of template workflows is also available, offering enhanced capabilities for variant annotation, extended quality control (QC), and advanced data visualization features.
In addition, dedicated tools are available to facilitate the calculation of tumor mutational burden (TMB) scores and the detection of copy number variants (CNVs) from whole-genome sequencing (WGS) data.
The QIAGEN CLC LightSpeed Module is frequently updated. A detailed list of new features, improvements, bug fixes, and changes is available at https://digitalinsights.qiagen.com/clc-lightspeed-module-latest-improvements/.