This tool downloads the 3D Protein Structure Database from a public accessible HTTP location hosted by QIAGEN Aarhus.
The database contains a curated set of sequences with known 3D structures, which are obtained from the Protein Data Bank (http://www.wwpdb.org) [Berman et al., 2003]. The information stored in the database (e.g. protein sequence, X-ray resolution) is used to identify suitable structural templates when using the Link Variants to 3D Protein Structure tool.
To download the database, select:
Toolbox | Add Information to Variants () | Download 3D Protein Structure Database ()
If you are connected to a server, you will first be asked about whether you want to download the data locally or on a server. In the next wizard step you are asked to select the download location (see figure 22.26).
The downloaded database will be installed in the user home directory in a folder named CLCdatabases.
When new databases are released, a new version of the database can be downloaded by invoking the tool again (the existing database will be replaced).