Many proteins are integral membrane proteins. Most membrane proteins have hydrophobic regions which span the hydrophobic core of the membrane bi-layer and hydrophilic regions located on the outside or the inside of the membrane. Many receptor proteins have several transmembrane helices spanning the cellular membrane.

For prediction of transmembrane helices, we use TMHMM version 2.0 [Krogh et al., 2001] located at, thus an active internet connection is required to run the transmembrane helix prediction. Additional information on THMHH and Center for Biological Sequence analysis (CBS) can be found at and in the original research paper [Krogh et al., 2001].