The technical set-up of CLC Bioinformatics Database involves a database back-end and a server middle layer that the Workbench connects to. This server layer also has a web interface, which is used for administration and which also has very basic capabilities for uploading and downloading non-NGS data, and basic functionality for browsing and searching for data. The primary way to work with data stored in the CLC Bioinformatics Database would be to use a CLC Workbench.